The way AMD pushes their drivers, any overclocking is likely to destabilize some games. "IRQ not less or equal" is almost always a driver fault (or a hardware fault causing a driver fault). Cutscenes, opening doors, and events like that involve mode switches (between 2D and 3D, and at these times, the drivers are changing clock frequency and supply voltage. If anything can go wrong, it is most likely to go wrong at these times.

If you are overclocking, the first thing to try is to remove overclock (even factory overclock) and overvoltage settings. If that isn't enough, look for heating problems; this is especially a concern with TWEE, which (opposite of TW2) pushes the GPU hard in 2D mode (!). Especially if you see display artifacts before a crash, think heating problems.

This is not a criticism of AMD. nVidia does the same exact thing, because desktop GPU makers compete on 3D performance. Speed-selected chips have little margin of safety, and changes to get more performance out of DX11 reduce even that. ›››

Any BSOD is not a good sign. Could possibly be driver issues or possibly something more serious. Might be a good idea to post your system specs. ›››

Yes it tells me what .dll files are in use when the game crashes. Does it crash in other places like in opening doors or entering new areas? Where are you in the game? ›››

Try disabling auto save and the Steam overlay. If autosave is disabled then be sure and do the F5 quite a bit. You probably need to clear out some saves from time to time by either moving them to another folder or deleting them. ›››