You can use a critical attack to disable a vampire's poisoning attack, hitting the organ responsible for it's regeneration and even instakill them by piercing BOTH their hearts simultaneously.
Quote from gameinformer.
I was thinking about it and have an idea. When Geralt have full stamina and your enemy is beat down enough, after some attack you get prompt to execute finishing move. To execute it you click button and then camera focus on enemy, time slow down, crosshair appear and you need to aim at enemy's weak spot. You have brief moment for that, for example 1 second in the first level and with maxed out critical strikes you have 3 seconds. All creatures have different weak spots and you never get any hint where to strike, you need remember that from glossary or books. After executing it, We get something like finishing moves from witcher 1, all stamina is lost whenever you succeed or fail.
What do you guys think?